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In the meantime, patients can explore existing weight loss medications like semaglutide (Ozempic and Wegovy) and tirzepatide (Zepbound and Mounjaro)

Interest in such applications is largely driven by their proposed mechanisms of action, including enhancement of tissue repair, modulation of inflammation, and cytoprotective effects observed in preclinical studies

Westblade, L

However, under pathological conditions, activated MMPs are associated with increased degradation of ECM components and are involved in ECM re-modeling (Dollery et al., 40 oligomers can increase MMP-2 activity in stimulated astrocytes and correlated with increased oxidative stress, inflammation and reduced cell viability