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Future research should leverage advanced techniques like spatial multi-omics analysis and patient-derived organoids/assembloids to directly validate how iron accumulation drives senescence and fibrosis in this disease, which is crucial for translating this hypothesis into clinical practice

Bone age was 8 years

10.1016/j.nbd.2024.106520 61 GarlandE

Pallav Sengupta, orcid.org/0000-0002-1928-5048 Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers