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In this review, we proposed that there are two main insults that precipitate hyperoxia-induced AKI: (1) dysfunction due to reduced renal blood flow and alteration of the lung-heart-kidney axis, and (2) cellular harm due to inflammation and oxidative stress

Free Radic Biol Med 122:110115 Lisenbee CS, Lingard MJ, Trelease RN (2005) Arabidopsis peroxisomes possess functionally redundant membrane and matrix isoforms of monodehydroascorbate reductase

Consequently, additional studies with well-characterized in vivo and in vitro models are necessary to identify direct mechanistic evidence in comparison with extrapolative evidence and define the exact mechanism of control by this axis in luteal physiology

This vasodilatory effect may contribute to improved blood flow to injured tissues and enhanced healing capacity