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As of September 2023 it is on the FDA's Category 2 list of bulk drug substances that may not be compounded due to significant safety risks, and the agency has scheduled a Pharmacy Compounding Advisory Committee (PCAC) review for July 2026 covering proposed uses in opioid withdrawal, chronic insomnia, and narcolepsy

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DMF/MMF actions may also be indirect, including blocking of cytokine-activated I-B, a cytoplasmic complex that can induce degradation of a NF-B inhibitor, releasing inflammatory transcription factors to the nucleus to induce inflammation