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Similarly, chemogenetic activation of this circuit reversed morphine-induced constipation in mice, including significantly increased the output and water content of feces, as well as a significant higher transit rate and motility of the small intestine in hM3Dq-expressing mice than mCherry-expressing controls (Supplementary Fig

M., Lin, H

Nonpharmacologic measures for treating osteoarthritis include joint protection and splinting, physiotherapy, orthotic prostheses to support the feet, and joint replacement surgery