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Direct force on the powder can damage the peptide structure and reduce potency

96 A randomized controlled trial that included 40 subjects with insomnia and 40 healthy subjects found eight weeks of treatment with ashwagandha improved sleep parameters more than placebo in both participant groups, although the effects were more pronounced in those with insomnia

Berberine also restored protein phosphate 2A (PP2A) activity and glycogen synthase kinase 3 (GSK-3) activity (GSK-3 Tyr216 and Ser9 site phosphorylation increased) (Yu et al., 2011)

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