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Ratio: The ALT: AST ratio is typically 1:1 initially

Butyrate acts as a HDAC inhibitor in immune cells, suppressing the expression of pro-inflammatory cytokines (TNF-, IL-6) and enhancing the integrity of epithelial tight junctions

As such, secondary outcomes include changes in cognition, disease severity and function before and after treatment and across the one-year study period and measures of senescence and AD biomarkers in CSF pre- and post-treatment (baseline and three months) with an optional end of study collection

Damage to the endothelium is a hallmark of diabetic complications, and reduced glutathione levels correlate with worsening endothelial dysfunction