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However, glutathione levels decrease as you age, and natural production can also be slowed because of disease, medications, stress, trauma, infections, a poor diet, pollution, and radiation

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Also, the over expression of AtGSTF2 has been found to provide tolerance toward phenol stress in plants (Xu et al., 2017)

Side effects like telangiectasia, atrophy, acneiform eruption, hypertrichosis, striae, and glaucoma with periorbital usage as well as the suppression of hypothalamic-pituitary-adrenal axis due to systemic absorption can be minimized by intermittent use