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Failure of the autophagosomal-proteasomal functions accounts for a substantial percentage of sporadic PD cases (reviewed in Maloney and Lahiri, 2016

Another group independently also concluded that disability progression and brain atrophy occur earlier than in the classical secondary progressive stage, with many relapsing patients exhibiting insidious progression without clinical or radiographic evidence of inflammatory disease activity, coining the term silent progression (Cree et al., 2019)

To Lisas point, too, they go over the evidence-based treatment, but also evidence-based lifting modifications and behavioral things thats evidence-based

Dihexa (no longer available to prescribe) a peptide that has been shown to be similar to but much more powerful than BDNF (brain-derived-neurotrophic factor)