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Finally, NPs have been associated with multiple cell death pathways, including ferroptosis (via p53-mediated ferritinophagy and GPX4 depletion), pyroptosis (via TSC2/TFEB-related lysosomal defects), and intrinsic apoptosis, indicating context-dependent terminal outcomes for neuronal homeostasis ( 3.5 Changes in neurotransmitter and synaptic function Understanding how MPs and NPs affect neurotransmission requires reconciling limited and often conflicting evidence, which currently points to a highly context-dependent nature of neurotoxicity

Craig R

High concentrations of ATP, GDP, or other nucleotides influence the GEVAL fluorescent signal for GTP by less than 10% [20]