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Description

Circadian Rhythm Disruption as a Root Cause of DepressionCircadian clock gene variants in CLOCK, BMAL1, PER, CRY, NPAS2, and OPN4 interact with light exposure to disrupt hormones, sleep, and mood, increasing risk for depression, anxiety, and seasonal affective disorder

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A: It may interact with certain medicines such as Levodopa or antiepileptic drugs

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Renal impairment has a significant effect on clearance of these drugs, with important clinical consequences

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