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424 Cytoplasmic NADH from the glycolytic pathway is delivered to mitochondria through two NADH shuttles, G3P shuttle and MA shuttle, allowing NAD + recycling to sustain glycolytic flux

At 12 min past IV injection, almost all of the AOD9604 had cleared from the blood plasma, resulting in a relatively small AUC

It is generally accepted that in vitro studies with concentrations of active compounds beyond the IC50 concentration of 25 M for pure compounds and the IC50 of 100 g/mL for the extracts have no therapeutic significance because they could not be implemented in vivo and are not appropriate for further pharmaceutical development [272]

ISBN 9780857113382