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Activating transcription factor 4 (ATF4) can directly bind to the promoters of both PHGDH and PSAT1 and promote their expression under amino acid deprivation and hypoxia (Ye et al., 2012

The absorbance of the converted dye was measured at 540 nm using the Multiskan GO reader (Thermo Fisher Scientific), and the results were expressed as a percentage (%) compared with the vehicle treatment

The physiological significance of the PMRS is not completely understood, but it was reported that the increased PMRS activity in erythrocytes during aging may be a protective mechanism of the system for efficient extracellular dehydroascorbate reduction and ascorbate recycling under conditions of increased oxidative stress (173)

The main types are alcoholic fatty liver disease and nonalcoholic fatty liver disease (NAFLD)