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13 Patients with a genetic mutation, MTHFR C677T, which results in homocysteine metabolic deficiency, should avoid methionine supplements

Pasca et al., 2018

While everyone needs B12, some populations are at greater risk for deficiency

However, patients with irritable bowel syndrome or IBD are better off with a low-FODMAP diet, as it can exacerbate disease symptoms due to gas production and stretching of the intestinal lumen [8, 130,131,132]