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If there is clinical improvement and if a reticulocyte response is observed, the same amount may be given on alternate days for seven doses, then every 3 to 4 days for another 2 to 3 weeks

Cherney K

Anecdotal reports from Phase 2 participants suggest that nausea severity is higher when dosing occurs in the early morning on an empty stomach, possibly because fasting amplifies the compound's gastric-slowing effect

Larazotide has been evaluated in multiple Phase 2 clinical trials in celiac disease patients, where it reduced intestinal permeability, decreased gastrointestinal symptoms, and attenuated the immune activation triggered by gluten challenge