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sabdariffa significantly lowered plasma aldosterone levels and inhibited renin activity

Dietary supplementation with KG has demonstrated anti-inflammatory effects in chronic inflammation and COVID-19 models [68, 69]

As expected, silencing of endogenous KEAP1 increased luciferase activity driven by ARE elements under Cyss depletion conditions, whereas simultaneous expression of exogenous shRNA-resistant KEAP1 restored basal expression (Fig