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Signal Transduct Target Ther 6(1)

GHK-Cu, first identified in 1973 from mammalian plasma, functions as a naturally occurring copper-peptide complex that influences approximately 31% of the human genome, resetting gene expression patterns to favor tissue repair while delivering bioavailable copper essential for enzymatic processes underlying collagen synthesis and antioxidant defense

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The localized and time-limited nature of angiogenic activity in wound healing models differs mechanistically from the sustained, dysregulated vascular recruitment characteristic of tumor growth