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Additionally, pathway enrichment analysis further revealed that these alterations corresponded to disruptions in key metabolic routes, including the glucose-alanine cycle, glucose metabolism, beta-oxidation of very long-chain fatty acids, glutathione metabolism, transfer of acetyl groups into mitochondria, and the degradation pathways of branched-chain aminoacids (BCAA) (Figure S3)

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Zhang L, Rao F, Zhang K, Khandrika S, Das M, Vaingankar SM, Bao X, Rana BK, Smith DW, Wessel J, Salem RM, Rodriguez-Flores JL, Mahata SK, Schork NJ, Ziegler MG, OConnor DT

These enzymes work alongside glutathione to maintain plasma antioxidant levels and support immune function