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The interaction between the Gly-His-Lys peptide and fibroblasts is believed to potentially initiate a cascade of biological events leading to the synthesis of collagen, thereby playing a potential role in the mechanisms of tissue repair and regeneration

Cancer Treat Rev, 36 , 377-83

This iron-overloaded and pro-oxidative milieu creates conditions conducive to ferroptosis in ectopic endometrial tissue in endometriosis

Crucially, the ROS generated during GSH degradation by CHAC1 may also cause further TP53 mutations, creating a vicious self-reinforcing cycle: CHAC1 activity promotes the very TP53 mutations that allow the tumor to exploit CHAC1s harmful effect for growth