However, in recent years, multiple studies have shown that IgG accumulates abnormally during the aging process and become an important factor driving tissue degeneration and metabolic decline
ClinicalTrials.gov identifier: NCT01419691
Concurrently, altered glucose metabolism in the orbitofrontal cortex and limbic regions reflects energy deficits and mitochondrial dysfunction, contributing to the severity of psychiatric symptoms, such as paranoia, agitation, and mood disturbances ( MRI studies have further identified gray matter atrophy in the prefrontal cortex, medial cingulate gyrus, and hippocampus, regions that are critically involved in memory, decision-making, and emotional regulation (Thompson et al., 2004)
PUVA is primarily utilized for patients with deeper pigmentation and for higher-level phases [247, 248]