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Mediating its effects via AMPK-centric pathways, adiponectin hinders the Th0 cell differentiation to both Th1 and Th17 cell lines, which results in a diminished population of IFN-+ T cells ( In vitro assessments underscore adiponectins capacity to reduce IL-17 generation in skin T cells in the presence of IL-23 stimulus ( 3.3.2 Leptin Produced predominantly by subcutaneous adipose tissue, leptin, a polypeptide weighing 16 kDa, arises from the ob gene situated within the chromosomal region of 7q31.3