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Differential expression and GSEA analyses were performed as previously described 93,94

and Geier M.R

When applied consistently, GHK-Cu peptides begin working immediately to improve the cellular matrix, strengthen skin integrity, and accelerate dermal repair

Pivoting to the formulas efficacy, the overwhelming majority of the ingredients or ingredient combinations found in Muselys five Spot Cream formulas are mentioned as treatments for melasma by the American Academy of Dermatology (AAD), including:40 Hydroquinone Tretinoin and a mild steroid Triple combination cream (tretinoin, a corticosteroid, and hydroquinone) Azelaic acid Vitamin C Kojic acid Additionally, hydroquinone either alone or paired with tretinoin and a mild steroid (the triple combination cream mentioned above) were dubbed two of the most effective treatments for melasma in a 2020 review.6 This means that the M+, Erase, and Nurture formulas all have decent potential to be successful hyperpigmentation treatments