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Brain Structure and function related to depression in Alzheimers Disease: Contributions from neuroimaging research

These modifications dramatically reduce binding affinity to IGF-binding proteins (IGFBPs) the regulatory proteins that normally sequester and deactivate circulating IGF-1

Interestingly, it may be that these findings are showing that the minimal effective drug concentration very rapidly reaches the brain (i.e., at 1 min), because there is no change in time and dose-concentration