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Haidar A, Tsoukas MA, Bernier-Twardy S, et al

The signs and symptoms of the deficiency may include anemia, the buildup of too much acid in the body (metabolic acidosis), frequent infections, and symptoms caused by problems in the brain including seizures, intellectual disability, and loss of coordination (ataxia)

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5.2.2 Compound-specific toxicity thresholds and safety profiles 5.2.2.1 Curcumin: hepatotoxicity emergence and bioavailability concerns Recent evidence has highlighted emerging hepatotoxicity concerns associated with curcumin, particularly in the context of enhanced bioavailability formulations