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Preclinical work in obese murine models suggests that encapsulated 5-Amino-1MQ administration led to decreases in overall body weight and reductions in white adipose mass

In some embodiments, a concentration of the otoprotectant is at least or about 0.001 mM, 0.005 mM, 0.01 mM, 0.05 mM, 0.10 mM, 0.5 mM, 1 mM, 5 mM, 10 mM, 20 mM, 30 mM, 40 mM, 50 mM, 60 mM, 70 mM, 80 mM, 90 mM, 100 mM, 120 mM, 140 mM, 160 mM, 180 mM, 200 mM, or more than 200 mM

This allows it to directly neutralize reactive oxygen species (ROS) and reactive nitrogen species (RNS), such as hydroxyl radicals, superoxide anions, and peroxynitrite