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doi: 10.1093/ajcn/86.4.1016

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However, some smaller molecules like retinoids and Vitamin C can penetrate deep into the live cells of the spinous layer, helping to stimulate cell turnover and providing antioxidant support

Potential of these effects may be heightened in patients with breast cancer treated with hepatically metabolized chemotherapeutics (e.g., cyclophosphamide, paclitaxel, anthracyclines) or tyrosine kinase inhibitors in which drug-drug interaction-based elevation or lowering of enzyme activity can result in supra-therapeutic drug concentrations, accumulation of toxic metabolites and compromised detoxification of reactive oxygen species facilitating hepatocellular distress