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The whole body ratio of glutamine to glutamate is also predictive of disease, particularly type 2 diabetes

In these disorders, the coexistence of M1 and M2 macrophages results in the formation of complex cellular networks, which exacerbate persistent inflammation and fibrosis, further accelerating disease progression

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2.2.1 Cystine/glutamate transporter (Xc-system) The cystine/glutamate transporter (Xc-system) comprises disulfide-bonded heterodimers solute carrier family 7 member 11 (SLC7A11, also known as xCT) and SLC3A2, which form a membrane transport protein system that is responsible for transporting extracellular cystine and intracellular glutamate across the cell membrane at a 1:1 ratio