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There is one open-label intravenous safety pilot in two healthy adults, who received single doses of 10 mg and 20 mg with no comparator, no blinding, and short-term observation limited to vital signs, self reported symptoms and labs across two days [4]

However, early on, loop diuretics seemed to inherit the perceived metabolic effects of hydrochlorothiazide (Toivonen and Mustala, 1966)

Schwann cells producing matrix metalloproteinases under Mycobacterium leprae stimulation may play a role in the outcome of leprous neuropathy

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