WARNINGS: Patients with early Leber's disease (hereditary optic nerve atrophy) who were treated with cyanocobalamin suffered severe and swift optic atrophy
They slow gastric emptying, increase satiety, act on appetite signaling in the brain, and enhance glucose-dependent insulin secretion
Consistent with the distribution of Firmicutes in the cecal samples, the relative abundance of Ileibacterium was highest in the WD controls (average relative abundance 68%), second highest in the LD controls (average relative abundance 51%), and lowest in the vehicle- and 5A-1MQ-treated mice switched from WD to LD (average relative abundances of 40% and 41%, respectively)
For most compounds the headline safety question is what are the side effects? For 5-Amino-1MQ the honest headline is we do not yet know, and the correct response to not-knowing is conservatism documented doses, scheduled breaks, and a licensed clinician in the loop rather than assuming the absence of reported effects means the absence of risk