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The lack of standardized methods to evaluate total antioxidant capacity and the oxidation state and the use of inadequate antioxidants and/or improper concentrations of antioxidants lead to failure of numerous clinical trials directed to prevent or mitigate progression of atherosclerosis (230233)

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In experimental animal models, FOXO4-DRI preferentially targets senescent cells while largely sparing healthy cells, although its safety and selectivity in humans remain unknown