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Disruption of redox coupling can be seen in experimental models where astrocyte-specific mutations in the superoxide dismutase gene lead to enhanced motor neuron degeneration, an effect mitigated by mitochondrial-targeted antioxidants like MitoQ ( 4 Sleep disturbances and impaired brain metabolism are closely interconnected, both contributing significantly to the aging process Sleep is an active process initiated and supported by distinct neural populations within the brain

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COMT is involved in the inactivation of catecholamine neurotransmitters such as epinephrine, norepinephrine, and dopamine, but also catecholestrogens and catechol drugs such as the antiParkinsons disease agent LDOPA and the antihypertensive methyldopa (Weinshilboum et al., 1999)