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Taken together, the in-vivo E-peptide literature partially rehabilitates the idea that the E-domain does something, while simultaneously demolishing the simplistic version of the story: the effects are context-dependent, age-dependent, only partly receptor-independent, and not unambiguously beneficial even in mice

Ipamorelin, being a bit more potent, might offer slightly quicker results for some, but the general timeline for seeing significant physical changes is often similar think weeks to months rather than days

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