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Rice is also the surgical PI on a prospective randomized trial to evaluate the hemostatic effects of aprotinin during extrapleural pneumonectomy

VerduciEMartelliAMinielloVLandiMMarianiBBrambillaMet al (2017)

[7] Use during pregnancy is contraindicated due to the risk of birth defects

Under conditions of chronic stress or systemic inflammation, enzymes such as indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) are upregulated, diverting TRP metabolism away from 5-HT synthesis toward KYN production, with profound consequences for both peripheral physiology and central nervous system (CNS) function