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This is, unfortunately, a common occurrence as we age Vegan or vegetarian diet as most B12 foods are from animal sources Excessive alcohol consumption Toxic metal exposure Some Auto-immune conditions Certain genetic polymorphism Some medications like antacids, anti-histamines, and some blood-sugar-lowering drugs

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The molecule is permeable to cell membranes (confirmed by Caco-2 assay) and highly selective, without inhibitory effect on other SAM-dependent methyltransferases

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