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In some embodiments, the otic formulation or composition comprises about 0.9% by weight of the poloxamer

Moreover, the authors extended this mechanism to senescent cancer cells and demonstrated that these cells are more efficient than immunogenic cell death to induce immune system protection against tumor relapse

The most extensively studied signaling pathway is triggered by the activation of PRRs, specifically Toll-like receptors (TLRs) and RIG-I-like receptors (RLRs) [213, 214]