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Haem-iron acquisition in NTHi is regulated in accordance with environmental iron-bioavailability by iron-repressive transcriptional regulators such as fur , with the result that iron uptake is coordinated with storage and efflux to ensure iron homeostasis ( 3.3 Dysregulation of host haem-iron homeostasis High iron availability has been shown to increase the pathogenic potential of many bacteria in tissue and animal infection models by enhancing growth, cellular adhesion, invasion and epithelial damage (Reid et al., 2009

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