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Tests involving multiple factors were analyzed using either a three-way analysis of variance (ANOVA) with diet, time, and sex as variables, a two-way ANOVA with diet and time as variables, followed by Sidaks post hoc test, a two-way repeated measures (RM) ANOVA for longitudinal data, followed by Dunnetts post hoc test or by one-way ANOVA followed by Tukeys post hoc test as specified in the figure legends