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Calculation: Animal Dose (mg/kg) x (Mouse Km / Human Km) Math: 15 x (3 / 37) = 1.21 mg/kg

Insulin down regulates the transcription of cystathionine beta synthase (CBS), the main enzyme for Hcy elimination [3]

Here, most effects were found in pathways citric acid cycle and respiratory electron transport (q-value: 3.5 * 10 10 , 63 DEGs out of 171 genes, 76.2% downregulated), glucose metabolism (q-value: 9.9 * 10 9 , 36 DEGs out of 77 genes, 80.5% downregulated) and metabolism of lipids and lipoproteins (q-value: 2.9 * 10 6 , 165 DEGs out of 728 genes, 55.2% downregulated)

Another study found that in mice deficient in CD4 + T-cells, the gastric mucosa was heavily infiltrated by CD8 + T-cells and leading to a more severe disease (Tan et al., 2008)