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Further, glutathione metabolism dysregulation has been shown to induce diseases to the central nervous system, frailty and sarcopenia, infections, chronic liver diseases, metabolic diseases, pulmonary, and cardiovascular diseases [14]

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Combination Therapy of FLT3 Tyrosine Kinase Inhibitors and BH3 Mimetics Targeting Antiapoptotic MCL-1 Synergistically Eliminates FLT3-ITD Acute Myeloid Leukemia Cells in Vitro and In Vivo