Moreover, in H4IIE cells, a rat hepatoma cell line, that were stably transfected with the cDNA for the 2-oxoglutarate carrier, exhibited increased uptake of GSH and 2-oxoglutarate and were protected from cytotoxicity induced by hydrogen peroxide, methyl vinyl ketone, or cisplatin, demonstrating the protective function of increased mitochondrial GSH transport and mGSH levels in the liver (153)
Glutathione is made up of three amino acids: Glutamic acid, Cysteine and Glycine
Fluorescence-based measurement of cystine uptake through xCT shows requirement for ROS detoxification in activated lymphocytes
However, excessive intake of glutathione can lead to digestive issues such as diarrhea, nausea, vomiting, abdominal pain, skin rashes or itching, and difficulty breathing