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Unfortunately, the majority of promising therapies in animals have failed to successfully translate into clinical therapies for HT (66), and we are still lacking applicable translational therapeutic options to reach the CNS

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The fragment reproduces the cytoskeletal and migratory effects of full T4 in preclinical models but does not include all of the parent protein's non-actin functions

The aim of this paper is to identify theoretical, methodological, and operational references for an innovative planning system which, through the implementation of public transport networks, can trigger regeneration processes within the consolidated city