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ALA may also prevent renal dysfunction and kidney injury by suppressing the overexpression of endothelin-1 in renal ischemia reperfusion injury [82]

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The body will try its hardest to maintain equilibrium by activating various autonomic and reactive compensatory responses which are the neurological and endocrine systems, but unfortunately, the bodys crude response together with the damaged receptor sites and the impaired metabolic and detoxification pathways give rise to paradoxical and exaggerated responses