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This regulatory effect of DMF was identified through NRF2-dependent and independent mechanisms with NRF2 binding to ARE motifs and increasing DNA 5hmC of individual gene regulatory regions involved in the TSS pathway, cystine uptake, and GSH generation

Collectively, Scrophularia radix exerts synergistic effects on energy metabolism and inflammation suppression through the AMPK signaling pathway

The glutathione assay method utilizes an adaptation of Ellmans Reagent (DTNB), where 5,5-dithiobis (2-nitrobenzoic acid) (DTNB) reacts with GSH to form the compound TNB (2-nitro-5-thiobenzoic acid), which is then quantified using HPLC analysis

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