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These modifications in metabolism pathways resulted in a substantial increase in the levels of 48 metabolites such as Xanthine, ascorbate, Cys-Gly, kynurenine, phenylalanine, 5-hydroxykynurenine, and others as outlined in Supplementary Figures 5A, B

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Akkermansia , Lactobacillus , Clostridiaceae , and Muribaculaceae , and a concomitant increase in pro-inflammatory taxa including Prevotellaceae , Proteobacteria , and pathobionts like Mucispirillum schaedleri (Park et al., 2023