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These processes play key roles to promote chemoresistance in tumors, where elevated GSH inactivates electrophilic chemotherapeutic agents (cisplatin, alkylators), GSTs enable drug conjugation, and MRP-catalyzed efflux reduces intracellular drug levels - while inhibiting therapy-induced oxidative stress at the same time

A., Talebian, M

Glutathione Peroxidase Activity Colorimetric Assay Kit Catalog No

But it is a story about supplying the rate-limiting building block, cysteine, so that hepatocytes can rebuild their own glutathione on demand not about flooding the bloodstream with the finished tripeptide in the hope of whitening skin