glutathione pathway oxidative stress Apoptosis and glutathione: beyond an antioxidant The Glutathione System: A Journey

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demonstrated the beneficial effect of protecting motor neurons from injury by stimulating the production of GSH, decreasing the volume of brain infarcts in SpragueDawley rat brain following middle artery carotid occlusion

Chromatin changes on the GSTP1 promoter associated with its inactivation in prostate cancer

Treatment of Arabidopsis seedlings with 5 mM H 2 O 2 increased GCL activity and resulted in a shift from the less active reduced form to the more active oxidized form, as determined by activity assays and immunoblot analysis (Hicks et al., Conservation of the disulfide linkage that mediates the monomer/dimer transition of GCL occurs across the plant kingdom (Gromes et al., Nicotiana tabacum ), Agrobacterium tumefaciens (a-proteobacteria), and Xanthomonas campestris (-proteobacteria) showed that the two proteobacterial GCL remain monomeric during redox changes, even though the disulfide is retained