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An evidence-based approach, like the one used in our sports injury care, prioritizes treatments that are proven to work and, just as importantly, are understood to be safe for long-term health
The suggestion that elevated IGF-1 levels may serve as a marker of risk has been long established [65,66], however several studies reported conflicting results, suggesting that IGF-1 was only a tumor marker rather than an etiologic factor in prostate cancer and as such was unsuitable as a long-term predictor of the disease [67,68,69,70]
52 A study in Cerro de Pasco (4300 m) showed higher CMS scores and Hb concentrations but lower SaO 2 and peak expiratory flow rate (PEFR) values in a chronic lower respiratory disease (CLRD) group than normal
Such functional plasticity renders mast cells less prone to desensitisation and enables a sustained contribution to chronic inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease (IBD) 7
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