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The analysis of the optimized structures of the MichaelisMenten complex indicate that the polar residues at position 13 (Cys or Ser) stabilize the deprotonated GS , which in turn acts as the catalytic Brnsted base and abstracts the proton at position C2 of substrate 7 (Extended Data Fig

Therefore, further investigations of NAD + in kidney diseases are required, especially focusing on the roles of NAD + in severe AKI, CKD, and senescent cells

Finally, as intracellular GSH synthesis partially contributed to tGSH levels in the TIF, we explored the impact of blocking GSH export through drug transporters 37

Catalase-like nanozymes Due to their good water solubility, high availability, and narrow emission spectrum, quantum dots have attracted significant interest in nanomedicine