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Pain Processing Mechanisms Central Sensitization (via mGlu2 receptor upregulation)[4][5] Neuroinflammation (modulates glial activation)[12][13] Mitochondrial Dysfunction (enhances ATP production, -oxidation)[2][13] Oxidative Stress (direct antioxidant activity)[2][13] Systemic Inflammation limited direct evidence SUMMARY OVERVIEW CLINICAL PEARLS 1

Furthermore, physical activity may preserve neuronal plasticity and improve learning as mice demonstrated enhanced performance in water maze tests following wheel running [160]

Storing it in its original box or in a dark part of the refrigerator is best practice

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