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J Cardiovasc Pharmacol Ther, 20, 157168 (2015)

Category 2 designation means the FDA identified these substances as presenting potential safety concerns and deemed them not currently eligible for routine compounding under Sections 503A or 503B of the Federal Food, Drug, and Cosmetic Act

Considering the remaining obstacles in melasma treatment, a deeper comprehension of its multifactorial pathogenesis can improve therapeutic outcome and overcome its high recurrence and resistance rates (Rajanala et al., 2019b

however, treatment with levothyroxine in hypothyroid cases had a significant association with an increase in vitamin C levels